Controlling Surface-Induced Nanocomposites by Lipoplexes for Enhanced Gene Transfer
نویسندگان
چکیده
منابع مشابه
Effect of surface chemistry on gene transfer efficiency mediated by surface-induced DNA-doped nanocomposites.
Surface-induced biomineralization represents an effective way of immobilizing DNA molecules on biomaterial surfaces to introduce DNA into cells in contact with or at an approximate distance from the biomaterial surfaces. Previous studies have investigated how the composition of mineralizing solutions affects the composition and pH responsiveness of nanocomposites and thus gene transfer efficien...
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Despite the great achievement in understanding the materials properties and powder engineering of LiFePO4, the chemical bonding at the surface has been almost ignored. Herein, we demonstrate that the undercoordinated Fe2+/Fe3+ redox couple at the surface gives a high barrier for charge transfer, but it can be stabilized by nitrogen or sulfur adsorption. The surface modification improves greatly...
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Positively-charged gene delivery agents, such as cationic liposomes, typically prepared by mixing a cationic lipid and a neutral lipid in a 1 : 1 molar ratio, exhibit a fundamental flaw: on the one hand, the charge encourages cell uptake; on the other hand, the charge leads to aggregation in vivo with anionic serum components. We herein report a more phase-stable analogue of the zwitterionic an...
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ژورنال
عنوان ژورنال: Journal of Nanomaterials
سال: 2015
ISSN: 1687-4110,1687-4129
DOI: 10.1155/2015/784836